|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
proteolytic cleavage
nuclear transcription factor
|
|
gptkbp:alternativeSplicing
|
ATF6α
ATF6β
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
neurodegenerative disease
|
|
gptkbp:biologicalProcess
|
transcription regulation
DNA-binding
|
|
gptkbp:discoveredBy
|
Ron Prywes
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
ATF6 gene
|
|
gptkbp:Entrez_Gene_ID
|
22926
ENSG00000118217
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Activating Transcription Factor 6
|
|
gptkbp:function
|
transcription factor
regulates unfolded protein response
|
|
gptkbp:HGNC_ID
|
HGNC:791
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATF6
|
|
gptkbp:locatedOnChromosome
|
1q23.3
|
|
gptkbp:location
|
endoplasmic reticulum membrane
|
|
gptkbp:OMIM
|
605537
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Atf6
rat Atf6
|
|
gptkbp:PDB
|
5V6N
|
|
gptkbp:regulates
|
ER stress response genes
|
|
gptkbp:relatedTo
|
protein folding
cellular homeostasis
ER stress
UPR (unfolded protein response)
|
|
gptkbp:UniProtID
|
Q99941
|
|
gptkbp:bfsParent
|
gptkb:Bip_(protein)
|
|
gptkbp:bfsLayer
|
6
|