heat shock protein 70 family
GPTKB entity
Statements (55)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:Hsp70_family
|
| gptkbp:cofactor |
gptkb:Bag1
DnaJ/Hsp40 GrpE Hsp110 |
| gptkbp:domain |
C-terminal substrate-binding domain
N-terminal ATPase domain |
| gptkbp:evolutionaryConservation |
highly conserved across species
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
protein folding
molecular chaperone prevention of protein aggregation assistance in protein transport |
| gptkbp:GO_term |
protein folding
response to stress chaperone-mediated protein transport |
| https://www.w3.org/2000/01/rdf-schema#label |
heat shock protein 70 family
|
| gptkbp:inducedBy |
heat shock
cellular stress |
| gptkbp:involvedIn |
unfolded protein response
apoptosis regulation protein homeostasis antigen processing cellular protection |
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:nucleus chloroplast mitochondria cytosol |
| gptkbp:member |
gptkb:HSPA12A
gptkb:HSPA12B gptkb:HSPA13 gptkb:HSPA14 gptkb:HSPA1L gptkb:HSPA2 gptkb:HSPA6 gptkb:HSPA9 gptkb:HSPA1A gptkb:HSPA1B gptkb:HSPA8 gptkb:HSPA5 |
| gptkbp:molecularWeight |
approximately 70 kDa
|
| gptkbp:regulates |
gptkb:heat_shock_factor_1_(HSF1)
transcriptional upregulation under stress |
| gptkbp:significance |
implicated in cancer
implicated in neurodegenerative diseases potential therapeutic target |
| gptkbp:structure |
substrate-binding domain
C-terminal lid domain conserved ATPase domain |
| gptkbp:bfsParent |
gptkb:Bip_(protein)
|
| gptkbp:bfsLayer |
6
|