|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Amyloid_precursor_protein
gptkb:APPI
Cerebral vascular amyloid peptide
PreA4
Protease nexin-II
ABPP
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
Cerebral amyloid angiopathy
|
|
gptkbp:encodedBy
|
gptkb:APP_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000142192
|
|
gptkbp:function
|
Involved in the pathogenesis of Alzheimer's disease
|
|
gptkbp:gene
|
gptkb:APP
|
|
gptkbp:GO
|
GO:0005515 protein binding
GO:0005886 plasma membrane
GO:0007155 cell adhesion
GO:0007268 synaptic transmission
|
|
gptkbp:hasIsoform
|
gptkb:APP695
gptkb:APP751
gptkb:APP770
|
|
gptkbp:HGNC_ID
|
620
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
UniProt:P11021
|
|
gptkbp:lastAnnotationUpdate
|
2022-02-23
|
|
gptkbp:latestReleaseVersion
|
1990-11-01
|
|
gptkbp:locatedOnChromosome
|
21
|
|
gptkbp:molecularWeight
|
87 kDa
|
|
gptkbp:name
|
gptkb:Amyloid_beta_A4_protein
|
|
gptkbp:OMIM
|
104760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1AAP
2LFM
5OQV
2M4J
6SHS
|
|
gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
Glycosylation
|
|
gptkbp:proteinFamily
|
APP family
|
|
gptkbp:RefSeq
|
NP_000475.1
|
|
gptkbp:reviewedBy
|
true
|
|
gptkbp:sequence
|
770
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:subcellularLocation
|
gptkb:Cell_membrane
gptkb:Golgi_apparatus
gptkb:Endoplasmic_reticulum
Secreted
|
|
gptkbp:taxonRank
|
9606
|
|
gptkbp:UniProt_entry_name
|
A4_HUMAN
|
|
gptkbp:UniProtKB_accession
|
P11021
|
|
gptkbp:bfsParent
|
gptkb:BiP
|
|
gptkbp:bfsLayer
|
8
|