ER-associated degradation (ERAD)
GPTKB entity
Statements (25)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cellular process
protein quality control pathway |
| gptkbp:alternativeName |
ERAD
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:diabetes
neurodegenerative diseases cystic fibrosis |
| gptkbp:function |
protein degradation
removal of misfolded proteins |
| https://www.w3.org/2000/01/rdf-schema#label |
ER-associated degradation (ERAD)
|
| gptkbp:involves |
gptkb:proteasome
gptkb:E3_ubiquitin_ligases ubiquitin-proteasome system p97/VCP ATPase retrotranslocation |
| gptkbp:occurredIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:regulates |
protein homeostasis
|
| gptkbp:relatedTo |
unfolded protein response
|
| gptkbp:studiedIn |
gptkb:yeast
mammalian cells |
| gptkbp:bfsParent |
gptkb:N-glycanase_1
gptkb:BiP_protein gptkb:KAR2 gptkb:yeast_Kar2p |
| gptkbp:bfsLayer |
7
|