Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
ER stress
|
| gptkbp:alias |
ERN1
IRE1α |
| gptkbp:amendedBy |
autophosphorylation
|
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes_mellitus neurodegeneration |
| gptkbp:discoveredBy |
gptkb:Kazutoshi_Mori
|
| gptkbp:domain |
protein kinase domain
endoribonuclease domain |
| gptkbp:EC_number |
2.7.11.1
|
| gptkbp:fullName |
Inositol-requiring enzyme 1
|
| gptkbp:function |
kinase
endoribonuclease unfolded protein response sensor |
| gptkbp:gene |
ERN1
|
| https://www.w3.org/2000/01/rdf-schema#label |
IRE1
|
| gptkbp:locatedOnChromosome |
chromosome 17q23.3
|
| gptkbp:location |
endoplasmic reticulum membrane
|
| gptkbp:molecularWeight |
110 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
IRE1α
IRE1β |
| gptkbp:pathway |
unfolded protein response
|
| gptkbp:PDB |
2HZ6
|
| gptkbp:substrate |
XBP1 mRNA
|
| gptkbp:UniProtID |
O75460
|
| gptkbp:bfsParent |
gptkb:Bip_(protein)
|
| gptkbp:bfsLayer |
6
|