|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
diffuse large B-cell lymphoma
chronic lymphocytic leukemia
follicular lymphoma
|
|
gptkbp:discoveredBy
|
gptkb:John_C._Reed
|
|
gptkbp:encodes
|
gptkb:Bcl-2
|
|
gptkbp:enemyOf
|
gptkb:BAD
gptkb:BID
gptkb:BAX
gptkb:NOXA
gptkb:PUMA
gptkb:BAK
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171791
596
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:firstDescribed
|
1984
|
|
gptkbp:fullName
|
gptkb:B-cell_lymphoma_2
|
|
gptkbp:function
|
regulation of apoptosis
inhibition of cell death
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:990
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BCL2 gene
|
|
gptkbp:inhibitedBy
|
caspase activation
|
|
gptkbp:locatedOnChromosome
|
18
18q21.33
|
|
gptkbp:mutationAssociatedWith
|
gptkb:translocation_t(14;18)(q32;q21)
|
|
gptkbp:OMIM
|
151430
|
|
gptkbp:orthologInMouse
|
gptkb:Bcl2
|
|
gptkbp:proteinFamily
|
gptkb:BH1
gptkb:BH4
gptkb:Bcl-2_family
transmembrane domain
BH3
BH2
|
|
gptkbp:regulates
|
gptkb:E2F1
gptkb:p53
gptkb:STAT3
gptkb:NF-κB
estrogen receptor
cytochrome c release
mitochondrial outer membrane permeabilization
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
nuclear envelope
mitochondrial outer membrane
|
|
gptkbp:symbol
|
gptkb:BCL2
|
|
gptkbp:targetOfDrug
|
gptkb:oblimersen
gptkb:venetoclax
|
|
gptkbp:UniProtID
|
P10415
|
|
gptkbp:bfsParent
|
gptkb:Bcl-2
gptkb:transcription_factor_Myb
gptkb:IGH_gene
|
|
gptkbp:bfsLayer
|
7
|