|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Bcl-2_alpha
gptkb:PPP1R50
BCL2L
Bcl-2 oncoprotein
|
|
gptkbp:associatedWith
|
gptkb:cancer
chronic lymphocytic leukemia
follicular lymphoma
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_J._Korsmeyer
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodedBy
|
gptkb:BCL2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000171791
|
|
gptkbp:expressedIn
|
gptkb:B_cells
lymphoid tissues
|
|
gptkbp:family
|
gptkb:Bcl-2_family
|
|
gptkbp:fullName
|
gptkb:B-cell_lymphoma_2
|
|
gptkbp:function
|
regulation of apoptosis
anti-apoptotic protein
|
|
gptkbp:gene
|
gptkb:BCL2
|
|
gptkbp:GO
|
GO:0006916 (anti-apoptosis)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bcl2
|
|
gptkbp:inhibitedBy
|
gptkb:Bax
gptkb:Bak
cell death
cytochrome c release
apoptosome formation
|
|
gptkbp:interactsWith
|
gptkb:Bax
gptkb:Bim
gptkb:Mcl-1
gptkb:Bak
Bad
|
|
gptkbp:locatedOnChromosome
|
18q21.33
|
|
gptkbp:location
|
mitochondrial outer membrane
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
leukemia
|
|
gptkbp:OMIM
|
151430
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
apoptosis pathway
intrinsic apoptotic signaling pathway
|
|
gptkbp:PDB
|
gptkb:1G5M
|
|
gptkbp:phosphorylates
|
Ser70
|
|
gptkbp:prevention
|
caspase activation
|
|
gptkbp:RefSeq
|
NM_000633
|
|
gptkbp:regulates
|
mitochondrial membrane permeability
|
|
gptkbp:structure
|
contains BH1, BH2, BH3, BH4 domains
|
|
gptkbp:target
|
gptkb:oblimersen
gptkb:venetoclax
|
|
gptkbp:translocationPartner
|
gptkb:t(14;18)(q32;q21)
|
|
gptkbp:UniProtID
|
P10415
|
|
gptkbp:bfsParent
|
gptkb:BCL2
|
|
gptkbp:bfsLayer
|
7
|