|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:BCL2
|
|
gptkbp:associatedWith
|
chronic lymphocytic leukemia
various cancers
follicular lymphoma
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_J._Korsmeyer
|
|
gptkbp:encodedBy
|
gptkb:BCL2_gene
|
|
gptkbp:family
|
gptkb:Bcl-2_family
|
|
gptkbp:firstDescribed
|
1984
|
|
gptkbp:function
|
regulation of apoptosis
|
|
gptkbp:geneType
|
tumor suppressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-cell lymphoma 2
|
|
gptkbp:inhibitedBy
|
gptkb:BAX
gptkb:BAK
apoptosis
|
|
gptkbp:interactsWith
|
gptkb:BAD
gptkb:MCL1
gptkb:BID
gptkb:BCL-XL
BIM
|
|
gptkbp:locatedOnChromosome
|
18q21.3
|
|
gptkbp:location
|
mitochondrial outer membrane
|
|
gptkbp:molecularWeight
|
~26 kDa
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:prevention
|
cytochrome c release
apoptosome formation
|
|
gptkbp:regulates
|
cell death
|
|
gptkbp:roleInCancer
|
tumor suppressor
|
|
gptkbp:structure
|
contains BH domains
|
|
gptkbp:target
|
gptkb:oblimersen
gptkb:venetoclax
|
|
gptkbp:bfsParent
|
gptkb:Bcl-2
gptkb:BCL2
gptkb:BCL2_family_proteins
|
|
gptkbp:bfsLayer
|
7
|