Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:BCL2
|
| gptkbp:associatedWith |
chronic lymphocytic leukemia
various cancers follicular lymphoma |
| gptkbp:discoveredBy |
gptkb:Stanley_J._Korsmeyer
|
| gptkbp:encodedBy |
gptkb:BCL2_gene
|
| gptkbp:family |
gptkb:Bcl-2_family
|
| gptkbp:firstDescribed |
1984
|
| gptkbp:function |
regulation of apoptosis
|
| gptkbp:geneType |
gptkb:tumor_suppressor
|
| gptkbp:inhibitedBy |
gptkb:BAX
gptkb:BAK apoptosis |
| gptkbp:interactsWith |
gptkb:BAD
gptkb:MCL1 gptkb:BID gptkb:BCL-XL BIM |
| gptkbp:locatedOnChromosome |
18q21.3
|
| gptkbp:location |
mitochondrial outer membrane
|
| gptkbp:molecularWeight |
~26 kDa
|
| gptkbp:overexpressedIn |
tumorigenesis
|
| gptkbp:prevention |
cytochrome c release
apoptosome formation |
| gptkbp:regulates |
cell death
|
| gptkbp:roleInCancer |
gptkb:tumor_suppressor
|
| gptkbp:structure |
contains BH domains
|
| gptkbp:target |
gptkb:oblimersen
gptkb:venetoclax |
| gptkbp:bfsParent |
gptkb:Bcl-2
gptkb:BCL2 |
| gptkbp:bfsLayer |
7
|
| http://www.w3.org/2000/01/rdf-schema#label |
B-cell lymphoma 2
|