Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chromosomal band
|
| gptkbp:alsoKnownAs |
gptkb:Philadelphia_chromosome
|
| gptkbp:associatedWith |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:chromosomeInvolved |
gptkb:chromosome_9
chromosome 22 |
| gptkbp:consequence |
constitutive tyrosine kinase activity
|
| gptkbp:cytogeneticNotation |
t(9;22)(q34;q11)
|
| gptkbp:diagnosticTest |
gptkb:FISH
gptkb:RT-PCR karyotyping |
| gptkbp:discoveredBy |
David Hungerford
Peter Nowell |
| gptkbp:discoveredIn |
1960
|
| gptkbp:frequencyInCML |
>90%
|
| gptkbp:fusionProtein |
gptkb:BCR-ABL_protein
|
| https://www.w3.org/2000/01/rdf-schema#label |
t(9;22) BCR-ABL
|
| gptkbp:involvedIn |
gptkb:ABL1
gptkb:BCR |
| gptkbp:result |
gptkb:BCR-ABL_fusion_gene
|
| gptkbp:targetOfDrug |
gptkb:bosutinib
gptkb:dasatinib gptkb:ponatinib gptkb:imatinib gptkb:nilotinib |
| gptkbp:bfsParent |
gptkb:pre-B-cell_acute_lymphoblastic_leukemia
|
| gptkbp:bfsLayer |
7
|