|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
MAP2Ks (MKK3, MKK6)
|
|
gptkbp:alsoKnownAs
|
gptkb:MAPK11
gptkb:Mitogen-activated_protein_kinase_11
|
|
gptkbp:encodedBy
|
gptkb:MAPK11_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000185386
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:function
|
signal transduction
inflammatory response
cellular response to stress
|
|
gptkbp:GO_term
|
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0000165 (MAPK cascade)
|
|
gptkbp:HGNC_ID
|
HGNC:6872
|
|
gptkbp:inhibitedBy
|
gptkb:SB203580
|
|
gptkbp:involvedIn
|
gptkb:cancer
neurodegenerative diseases
inflammatory diseases
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q13.1
|
|
gptkbp:memberOf
|
gptkb:MAP_kinase_family
gptkb:p38_MAP_kinase_family
|
|
gptkbp:molecularWeight
|
approximately 41 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3PY3
1CM8
3GP0
|
|
gptkbp:phosphorylates
|
gptkb:ATF2
gptkb:ELK1
gptkb:HSP27
gptkb:MAPKAPK2
gptkb:STAT1
transcription factors
|
|
gptkbp:RefSeq
|
NP_002744.2
|
|
gptkbp:relatedTo
|
p38alpha
p38delta
p38gamma
|
|
gptkbp:role
|
apoptosis
cell differentiation
cell cycle regulation
cytokine production
|
|
gptkbp:sequence
|
UniProt:P53778
|
|
gptkbp:structure
|
serine/threonine kinase
|
|
gptkbp:UniProtID
|
P53778
|
|
gptkbp:bfsParent
|
gptkb:MAPK11
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p38beta
|