Mitogen-activated protein kinase 11

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:MKK3 gptkb:MKK6 dual phosphorylation on threonine and tyrosine
gptkbp:alternativeName	gptkb:MAPK11 gptkb:p38_beta
gptkbp:associatedWith	gptkb:cancer neurodegenerative diseases inflammatory diseases
gptkbp:discoveredBy	1996
gptkbp:encodedBy	gptkb:MAPK11_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000185386 5600
gptkbp:enzymeClassification	gptkb:EC_2.7.11.24
gptkbp:expressedIn	various tissues
gptkbp:family	gptkb:MAP_kinase_family
gptkbp:function	signal transduction inflammatory response cellular response to stress
gptkbp:gene	gptkb:MAPK11
gptkbp:geneType	protein-coding
gptkbp:HGNC_ID	gptkb:MAPK11
gptkbp:inhibitedBy	gptkb:SB203580
gptkbp:involvedIn	cell differentiation cell proliferation apoptosis regulation
gptkbp:KEGGID	hsa:5600
gptkbp:locatedOnChromosome	gptkb:chromosome_22q13.33
gptkbp:molecularWeight	approximately 41 kDa
gptkbp:OMIM	602898
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Mapk11
gptkbp:pathway	gptkb:MAPK_signaling_pathway
gptkbp:PDB	3GC9
gptkbp:phosphorylates	gptkb:ATF2 gptkb:MAPKAPK2 gptkb:STAT1 transcription factors
gptkbp:ReactomeID	R-HSA-112409
gptkbp:RefSeq	gptkb:NM_002751
gptkbp:structureType	serine/threonine kinase
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:Q15759
gptkbp:bfsParent	gptkb:MAPK11
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Mitogen-activated protein kinase 11