Mitogen-activated protein kinase 11

URI: https://gptkb.org/entity/Mitogen-activated_protein_kinase_11
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:MKK3
gptkb:MKK6
dual phosphorylation on threonine and tyrosine
gptkbp:alternativeName gptkb:MAPK11
gptkb:p38_beta
gptkbp:associatedWith gptkb:cancer
neurodegenerative diseases
inflammatory diseases
gptkbp:discoveredBy 1996
gptkbp:encodedBy gptkb:MAPK11_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000185386
5600
gptkbp:enzymeClassification gptkb:EC_2.7.11.24
gptkbp:expressedIn various tissues
gptkbp:family gptkb:MAP_kinase_family
gptkbp:function signal transduction
inflammatory response
cellular response to stress
gptkbp:gene gptkb:MAPK11
gptkbp:geneType protein-coding
gptkbp:HGNC_ID gptkb:MAPK11
https://www.w3.org/2000/01/rdf-schema#label Mitogen-activated protein kinase 11
gptkbp:inhibitedBy gptkb:SB203580
gptkbp:involvedIn cell differentiation
cell proliferation
apoptosis regulation
gptkbp:KEGGID hsa:5600
gptkbp:locatedOnChromosome gptkb:chromosome_22q13.33
gptkbp:molecularWeight approximately 41 kDa
gptkbp:OMIM 602898
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Mapk11
gptkbp:pathway gptkb:MAPK_signaling_pathway
gptkbp:PDB 3GC9
gptkbp:phosphorylates gptkb:ATF2
gptkb:MAPKAPK2
gptkb:STAT1
transcription factors
gptkbp:ReactomeID R-HSA-112409
gptkbp:RefSeq gptkb:NM_002751
gptkbp:structureType serine/threonine kinase
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:Q15759
gptkbp:bfsParent gptkb:MAPK11
gptkbp:bfsLayer 7