|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:alternativeName
|
gptkb:NR3C4
|
|
gptkbp:discoveredBy
|
gptkb:E._L._Simpson
|
|
gptkbp:discoveredIn
|
1968
|
|
gptkbp:encodedBy
|
gptkb:AR_gene
|
|
gptkbp:expressedIn
|
gptkb:skin
gptkb:skeletal_muscle
gptkb:prostate
central nervous system
liver
ovaries
testes
hair follicles
|
|
gptkbp:function
|
regulates gene expression
binds androgens
|
|
gptkbp:gene
|
AR
|
|
gptkbp:hasPolymorphism
|
CAG repeat length
GGC repeat length
|
|
gptkbp:HGNC_ID
|
HGNC:644
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Androgen receptor
|
|
gptkbp:inhibitedBy
|
gptkb:progesterone
gptkb:spironolactone
gptkb:cyproterone_acetate
gptkb:ketoconazole
gptkb:dutasteride
gptkb:finasteride
androgen deprivation therapy
estrogens
|
|
gptkbp:interactsWith
|
gptkb:FOXA1
gptkb:BRCA1
gptkb:p300
gptkb:NCOA2
gptkb:SRC-1
heat shock proteins
coactivators
corepressors
AR coactivator ARA70
|
|
gptkbp:ligand
|
gptkb:dihydrotestosterone
testosterone
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xq11-12
gptkb:X_chromosome
|
|
gptkbp:memberOf
|
nuclear receptor subfamily 3 group C member 4
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:androgen_insensitivity_syndrome
gptkb:spinal_and_bulbar_muscular_atrophy
prostate cancer
|
|
gptkbp:OMIM
|
313700
|
|
gptkbp:PDB
|
gptkb:1E3G
|
|
gptkbp:regulates
|
libido
hair growth
erythropoiesis
bone density
male sexual development
sebaceous gland activity
spermatogenesis
voice deepening
muscle mass
secondary sexual characteristics
fat distribution
|
|
gptkbp:structure
|
DNA-binding domain
N-terminal domain
ligand-binding domain
hinge region
|
|
gptkbp:target
|
gptkb:abiraterone
gptkb:bicalutamide
gptkb:flutamide
gptkb:enzalutamide
antiandrogens
|
|
gptkbp:UniProtID
|
P10275
|
|
gptkbp:bfsParent
|
gptkb:Nuclear_Receptor_(biochemistry)
gptkb:P06493
|
|
gptkbp:bfsLayer
|
6
|