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gptkbp:instanceOf
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gptkb:protein
gptkb:enzyme
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gptkbp:alternativeName
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gptkb:p300
gptkb:KAT3B
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gptkbp:domain
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gptkb:HAT_domain
gptkb:KIX_domain
gptkb:TAZ_domain
gptkb:bromodomain
CH1 domain
CH2 domain
CH3 domain
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gptkbp:encodedBy
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EP300 gene
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gptkbp:expressedIn
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many human tissues
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
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histone acetyltransferase activity
transcriptional coactivator
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gptkbp:GO_term
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gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0004402 (histone acetyltransferase activity)
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https://www.w3.org/2000/01/rdf-schema#label
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E1A binding protein p300
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gptkbp:interactsWith
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gptkb:p53
CREB-binding protein (CBP)
E1A protein
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gptkbp:involvedIn
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apoptosis
cell differentiation
DNA repair
cell cycle progression
cell growth
regulation of gene expression
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gptkbp:locatedOnChromosome
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gptkb:chromosome_22q13.2
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gptkbp:location
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gptkb:nucleus
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gptkbp:molecularWeight
|
~300 kDa
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gptkbp:mutationAssociatedWith
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gptkb:cancer
gptkb:Rubinstein-Taybi_syndrome
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gptkbp:OMIM
|
602700
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gptkbp:PDB
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gptkb:4PZS
5HOB
5HOU
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gptkbp:postTranslationalModification
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phosphorylation
ubiquitination
acetylation
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gptkbp:regulates
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cell cycle genes
NF-kB activity
HIF1A activity
MYC activity
p53 acetylation
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gptkbp:requires
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embryonic development
neurogenesis
hematopoiesis
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gptkbp:UniProtID
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gptkb:Q09472
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gptkbp:bfsParent
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gptkb:EP300
gptkb:p300
gptkb:p300/CBP_family
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gptkbp:bfsLayer
|
8
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