Histone acetyltransferase

URI: https://gptkb.org/entity/Histone_acetyltransferase
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activity_measured_by acetylation assays
gptkbp:alternativeName gptkb:KAT
HAT
lysine acetyltransferase
gptkbp:amendedBy chromatin structure
non-histone proteins
gptkbp:associatedWith transcriptional activation
gptkbp:catalyzes transfer of acetyl group to lysine residues on histone proteins
gptkbp:cofactor acetyl-CoA
gptkbp:discoveredBy gptkb:yeast
gptkbp:dysregulationAssociatedWith gptkb:cancer
developmental disorders
neurological disorders
gptkbp:EC_number 2.3.1.48
gptkbp:example gptkb:CBP
gptkb:MOF
gptkb:p300
gptkb:GCN5
gptkb:GNAT_family
gptkb:MYST_family
gptkb:PCAF
gptkb:Tip60
gptkb:p300/CBP_family
gptkbp:foundIn eukaryotes
some prokaryotes
gptkbp:function acetylation of histones
gptkbp:GO_term GO:0004402
https://www.w3.org/2000/01/rdf-schema#label Histone acetyltransferase
gptkbp:inhibitedBy gene silencing
gptkbp:involves apoptosis
cell differentiation
signal transduction
learning
DNA repair
cell cycle regulation
metabolism
immune response
epigenetic regulation
memory formation
gptkbp:opposedBy histone deacetylase
gptkbp:regulates gene expression
gptkbp:substrate gptkb:histone_H2A
gptkb:histone_H2B
gptkb:histone_H3
gptkb:histone_H4
gptkbp:target small molecule inhibitors
therapeutic drugs
gptkbp:bfsParent gptkb:Enzymes
gptkbp:bfsLayer 6