neuroblastoma RAS oncogene homolog

URI: https://gptkb.org/entity/neuroblastoma_RAS_oncogene_homolog
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:abbreviation gptkb:NRAS
gptkbp:alias gptkb:NRAS_proto-oncogene,_GTPase
gptkb:neuroblastoma_RAS_viral_oncogene_homolog
gptkbp:associatedWith gptkb:cancer
gptkb:acute_myeloid_leukemia
colorectal cancer
melanoma
gptkbp:chromosomeArm 1p13.2
gptkbp:discoveredIn 1983
gptkbp:encodes gptkb:NRAS_protein
gptkbp:Entrez_Gene_ID gptkb:ENSG00000213281
4893
gptkbp:expressedIn various tissues
gptkbp:function signal transduction
GTPase activity
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 7989
https://www.w3.org/2000/01/rdf-schema#label neuroblastoma RAS oncogene homolog
gptkbp:length 189 amino acids
gptkbp:locatedOnChromosome 1
gptkbp:memberOf gptkb:RAS_gene_family
gptkbp:mutationAssociatedWith drug resistance
missense mutation
codon 12
codon 13
codon 61
oncogenic transformation
gptkbp:OMIM 164790
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Nras
gptkbp:pathway gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
gptkbp:regulates apoptosis
cell differentiation
cell proliferation
gptkbp:relatedTo gptkb:HRAS
gptkb:KRAS
gptkbp:target gptkb:MEK_inhibitors
gptkb:RAF_inhibitors
anticancer drugs
gptkbp:UniProtID gptkb:P01111
gptkbp:bfsParent gptkb:Neuroblastoma_RAS_viral_oncogene_homolog
gptkbp:bfsLayer 6