Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:alsoKnownAs |
Fas-mediated apoptotic pathway
|
| gptkbp:cause |
activation of caspases
|
| gptkbp:component |
gptkb:death-inducing_signaling_complex_(DISC)
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
autoimmune diseases |
| gptkbp:function |
induces apoptosis
|
| gptkbp:gene |
gptkb:FADD
gptkb:CASP8 gptkb:FAS gptkb:FASLG |
| gptkbp:GO_term |
gptkb:GO:0008625
|
| https://www.w3.org/2000/01/rdf-schema#label |
Fas signaling pathway
|
| gptkbp:inhibitedBy |
gptkb:c-FLIP
|
| gptkbp:involves |
gptkb:FADD
gptkb:Fas_ligand gptkb:caspase-8 gptkb:caspase-3 gptkb:Fas_receptor |
| gptkbp:launched |
Fas ligand binding to Fas receptor
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:partOf |
extrinsic apoptotic pathway
|
| gptkbp:regulates |
cell survival
immune homeostasis |
| gptkbp:relatedTo |
programmed cell death
immune system |
| gptkbp:studiedIn |
humans
mice |
| gptkbp:bfsParent |
gptkb:FADD
|
| gptkbp:bfsLayer |
7
|