Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
integrin
|
| gptkbp:alsoKnownAs |
GPIIb/IIIa
glycoprotein IIb/IIIa |
| gptkbp:binds |
gptkb:fibrinogen
gptkb:von_Willebrand_factor gptkb:fibronectin vitronectin |
| gptkbp:composedOf |
gptkb:ITGA2B
ITGB3 |
| gptkbp:discoveredIn |
1970s
|
| gptkbp:encodedBy |
ITGA2B gene
ITGB3 gene |
| gptkbp:expressedIn |
gptkb:megakaryocytes
|
| gptkbp:foundIn |
platelets
|
| gptkbp:function |
mediates platelet aggregation
|
| https://www.w3.org/2000/01/rdf-schema#label |
αIIbβ3 integrin
|
| gptkbp:locatedOn |
platelet plasma membrane
|
| gptkbp:molecularWeight |
235 kDa
|
| gptkbp:mutationAssociatedWith |
Glanzmann's thrombasthenia
|
| gptkbp:role |
thrombosis
hemostasis |
| gptkbp:structure |
heterodimer
|
| gptkbp:subunitAlpha |
αIIb
|
| gptkbp:subunitBeta |
β3
|
| gptkbp:target |
abciximab
eptifibatide tirofiban |
| gptkbp:bfsParent |
gptkb:integrins
|
| gptkbp:bfsLayer |
7
|