Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
integrin
|
| gptkbp:binds |
gptkb:fibrinogen
gptkb:fibronectin gptkb:osteopontin vitronectin thrombospondin |
| gptkbp:composedOf |
alphaV integrin subunit
beta3 integrin subunit |
| gptkbp:expressedIn |
gptkb:osteoclasts
endothelial cells some tumor cells |
| gptkbp:foundIn |
humans
other mammals |
| gptkbp:function |
signal transduction
cell adhesion |
| gptkbp:gene |
ITGB3
ITGAV |
| https://www.w3.org/2000/01/rdf-schema#label |
αvβ3 integrin
|
| gptkbp:involvedIn |
angiogenesis
tumor metastasis bone resorption |
| gptkbp:recognizedBy |
RGD motif
|
| gptkbp:role |
wound healing
vascular biology inflammation platelet aggregation |
| gptkbp:structure |
heterodimer
|
| gptkbp:target |
antagonist drugs
cilengitide |
| gptkbp:bfsParent |
gptkb:integrins
|
| gptkbp:bfsLayer |
7
|