|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:PTP-1B
gptkb:PTP1B
gptkb:PTP1B_phosphatase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:type_2_diabetes
obesity
|
|
gptkbp:discoveredBy
|
gptkb:Nicholas_K_Tonks
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
gptkb:PTP1B
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000196363
5770
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
|
|
gptkbp:fullName
|
gptkb:Protein_Tyrosine_Phosphatase,_Non-Receptor_Type_1
|
|
gptkbp:function
|
protein tyrosine phosphatase activity
negative regulation of insulin signaling
negative regulation of leptin signaling
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0004713
gptkb:GO:0004725
|
|
gptkbp:HGNC_ID
|
9642
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTPN1
|
|
gptkbp:inhibitedBy
|
gptkb:MSI-1436
gptkb:sodium_orthovanadate
gptkb:trodusquemine
|
|
gptkbp:locatedOnChromosome
|
gptkb:20q13.13
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:molecularWeight
|
50 kDa
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
altered glucose homeostasis
|
|
gptkbp:OMIM
|
176885
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Ptpn1
gptkb:rat_Ptpn1
gptkb:zebrafish_ptpn1
|
|
gptkbp:pathway
|
gptkb:leptin_signaling_pathway
insulin signaling pathway
|
|
gptkbp:PDB
|
gptkb:1PTY
gptkb:1SUG
gptkb:2HNP
|
|
gptkbp:regulates
|
gptkb:insulin_receptor
leptin receptor
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
endoplasmic reticulum membrane
|
|
gptkbp:UniProtID
|
gptkb:P18031
|
|
gptkbp:bfsParent
|
gptkb:Insulin_receptor
gptkb:protein_tyrosine_phosphatases
|
|
gptkbp:bfsLayer
|
6
|