insulin-like growth factor 1 receptor (IGF1R)

URI: https://gptkb.org/entity/insulin-like_growth_factor_1_receptor_(IGF1R)
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:cancer
growth disorders
gptkbp:binds insulin-like growth factor 1 (IGF-1)
insulin-like growth factor 2 (IGF-2)
gptkbp:discoveredIn 1980s
gptkbp:encodedBy gptkb:IGF1R_gene
gptkbp:expressedIn many tissues
gptkbp:function tyrosine kinase activity
mediates effects of IGF-1
https://www.w3.org/2000/01/rdf-schema#label insulin-like growth factor 1 receptor (IGF1R)
gptkbp:involvedIn cell differentiation
cell survival
cancer progression
cell growth
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome chromosome 15q26.3
gptkbp:molecularWeight ~180 kDa
gptkbp:OMIM 147370
gptkbp:orthologIn gptkb:insulin_receptor
gptkbp:PDB 3D94
gptkbp:phosphorylates autophosphorylation upon ligand binding
gptkbp:structure heterotetramer
gptkbp:subunit alpha subunit
beta subunit
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID gptkb:P08069
gptkbp:bfsParent gptkb:insulin_receptor
gptkbp:bfsLayer 7