insulin receptor substrate (IRS) proteins
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:domain |
gptkb:PH_domain
PTB domain |
| gptkbp:encodedBy |
IRS1 gene
IRS2 gene IRS3 gene IRS4 gene IRS5 gene IRS6 gene |
| gptkbp:foundIn |
mammals
vertebrates |
| gptkbp:function |
mediate insulin signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
insulin receptor substrate (IRS) proteins
|
| gptkbp:interactsWith |
gptkb:insulin_receptor
gptkb:IGF-1_receptor |
| gptkbp:member |
gptkb:IRS1
gptkb:IRS2 IRS3 IRS4 IRS5 IRS6 |
| gptkbp:phosphorylates |
gptkb:insulin_receptor
gptkb:IGF-1_receptor |
| gptkbp:relatedTo |
gptkb:type_2_diabetes
gptkb:metabolic_syndrome obesity |
| gptkbp:role |
cell differentiation
cell growth glucose metabolism insulin resistance |
| gptkbp:bfsParent |
gptkb:insulin_receptor
|
| gptkbp:bfsLayer |
7
|