|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:diseaseRelevance
|
tumor suppressor
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:expressedIn
|
many human tissues
|
|
gptkbp:function
|
GTPase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human Ras proteins
|
|
gptkbp:interactsWith
|
gptkb:GAPs
gptkb:GEFs
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
gptkb:SOS1
|
|
gptkbp:involvedIn
|
cell signal transduction
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:location
|
inner surface of plasma membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDBStructureAvailable
|
yes
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
methylation
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:reviewedBy
|
gptkb:NCBI_Gene
gptkb:OMIM
gptkb:UniProt
|
|
gptkbp:structure
|
small GTP-binding domain
|
|
gptkbp:subfamily
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:target
|
gptkb:MEK_inhibitors
farnesyltransferase inhibitors
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:D-Ras
|
|
gptkbp:bfsLayer
|
6
|