|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:FKHR
gptkb:FOXO1A
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
Alveolar rhabdomyosarcoma
|
|
gptkbp:encodes
|
gptkb:Forkhead_box_protein_O1
|
|
gptkbp:Entrez_Gene_ID
|
2308
ENSG00000150907
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
liver
adipose tissue
pancreas
|
|
gptkbp:family
|
forkhead box (FOX) family
|
|
gptkbp:formsFusionGeneWith
|
gptkb:PAX3
gptkb:PAX7
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
HGNC:3819
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human FOXO1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:CREBBP
gptkb:EP300
|
|
gptkbp:involvedIn
|
gptkb:PI3K-AKT_signaling_pathway
insulin signaling pathway
apoptosis pathway
|
|
gptkbp:length
|
655 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_13
13q14.11
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:mutationAssociatedWith
|
Alveolar rhabdomyosarcoma
translocation t(2;13)(q35;q14)
|
|
gptkbp:OMIM
|
136533
|
|
gptkbp:orthologInMouse
|
gptkb:Foxo1
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:SGK1
|
|
gptkbp:regulates
|
apoptosis
glucose metabolism
cell cycle
oxidative stress response
glycogenolysis
adipogenesis
gluconeogenesis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transcriptionalActivityRegulatedBy
|
gptkb:insulin
gptkb:AKT_kinase
|
|
gptkbp:UniProtID
|
Q12778
|
|
gptkbp:bfsParent
|
gptkb:C._elegans_DAF-16
|
|
gptkbp:bfsLayer
|
7
|