|
gptkbp:instanceOf
|
gptkb:transcription_factor
gptkb:protein
|
|
gptkbp:activatedBy
|
oxidative stress
|
|
gptkbp:alternativeName
|
gptkb:FKHR
gptkb:FOXO1A
|
|
gptkbp:encodedBy
|
FOXO1 gene
|
|
gptkbp:Entrez_Gene_ID
|
2308
ENSG00000150907
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
gptkb:skeletal_muscle
brain
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
apoptosis
cell cycle regulation
glucose metabolism
regulation of gene expression
oxidative stress response
insulin signaling pathway
|
|
gptkbp:GO
|
GO:0005634
GO:0003700
GO:0006355
|
|
gptkbp:HGNC_ID
|
HGNC:3819
|
|
gptkbp:inhibitedBy
|
gptkb:insulin
growth factors
|
|
gptkbp:length
|
655 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
13q14.11
|
|
gptkbp:memberOf
|
Forkhead box O subfamily
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:diabetes_mellitus
gptkb:rhabdomyosarcoma
Alveolar rhabdomyosarcoma
|
|
gptkbp:OMIM
|
136533
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3COA
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
|
|
gptkbp:RefSeq
|
NM_002015
|
|
gptkbp:regulates
|
gptkb:immune_response
muscle atrophy
adipogenesis
gluconeogenesis
|
|
gptkbp:UniProtID
|
Q12778
|
|
gptkbp:bfsParent
|
gptkb:FOXO1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Forkhead box protein O1
|