Forkhead box protein O1

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
transcription factor
gptkbp:activatedBy oxidative stress
gptkbp:alternativeName gptkb:FKHR
gptkb:FOXO1A
gptkbp:encodedBy FOXO1 gene
gptkbp:Entrez_Gene_ID 2308
ENSG00000150907
gptkbp:expressedIn gptkb:skeletal_muscle
brain
liver
adipose tissue
pancreas
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function apoptosis
cell cycle regulation
glucose metabolism
regulation of gene expression
oxidative stress response
insulin signaling pathway
gptkbp:GO GO:0005634
GO:0003700
GO:0006355
gptkbp:HGNC_ID HGNC:3819
https://www.w3.org/2000/01/rdf-schema#label Forkhead box protein O1
gptkbp:inhibitedBy gptkb:insulin
growth factors
gptkbp:length 655 amino acids
gptkbp:locale gptkb:nucleus
gptkb:cytoplasm
gptkbp:locatedOnChromosome 13q14.11
gptkbp:memberOf Forkhead box O subfamily
gptkbp:molecularWeight 70 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkb:diabetes_mellitus
gptkb:rhabdomyosarcoma
Alveolar rhabdomyosarcoma
gptkbp:OMIM 136533
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 3COA
gptkbp:phosphorylates gptkb:AKT1
gptkbp:RefSeq NM_002015
gptkbp:regulates muscle atrophy
immune response
adipogenesis
gluconeogenesis
gptkbp:UniProtID Q12778
gptkbp:bfsParent gptkb:FOXO1
gptkbp:bfsLayer 7