|
gptkbp:instanceOf
|
transcription factor
|
|
gptkbp:activatedBy
|
reduced insulin/IGF-1 signaling
|
|
gptkbp:alias
|
gptkb:DAF16
gptkb:FOXO_transcription_factor_DAF-16
FOXO homolog
|
|
gptkbp:binds
|
gptkb:DAF-16_binding_element_(DBE)
|
|
gptkbp:discoveredBy
|
gptkb:Cynthia_Kenyon
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:WBGene00000912
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:function
|
stress response
metabolic regulation
regulation of longevity
|
|
gptkbp:gene
|
gptkb:daf-16
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C. elegans DAF-16
|
|
gptkbp:inhibitedBy
|
gptkb:DAF-2
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_I
|
|
gptkbp:organism
|
gptkb:Caenorhabditis_elegans
|
|
gptkbp:orthologIn
|
gptkb:human_FOXO1
gptkb:human_FOXO3
gptkb:human_FOXO4
gptkb:human_FOXO6
|
|
gptkbp:phosphorylates
|
gptkb:AKT-1
gptkb:AKT-2
gptkb:SGK-1
|
|
gptkbp:proteinFamily
|
gptkb:FOXO
|
|
gptkbp:regulates
|
gptkb:ctl-1_gene
gptkb:dod-3_gene
gptkb:fat-6_gene
gptkb:hsp-16.2_gene
gptkb:ins-7_gene
gptkb:lys-7_gene
gptkb:mtl-1_gene
gptkb:sod-3_gene
apoptosis
innate immunity
antioxidant genes
dauer formation
fat storage
lifespan extension
stress resistance genes
|
|
gptkbp:requires
|
stress tolerance
dauer larva formation
longevity in insulin/IGF-1 mutants
|
|
gptkbp:sequence
|
553 amino acids
|
|
gptkbp:translocates_to
|
cytoplasm under normal conditions
nucleus under stress
|
|
gptkbp:UniProtID
|
gptkb:Q9U489
|
|
gptkbp:bfsParent
|
gptkb:FOXO_transcription_factors
|
|
gptkbp:bfsLayer
|
6
|