epidermal growth factor receptor (EGFR)

URI: https://gptkb.org/entity/epidermal_growth_factor_receptor_(EGFR)

GPTKB entity

Statements (61)

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:activatedBy	gptkb:MAPK/ERK_pathway gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway
gptkbp:alternativeName	gptkb:ERBB1 gptkb:HER1
gptkbp:binds	gptkb:epidermal_growth_factor_(EGF) gptkb:transforming_growth_factor_alpha_(TGF-α)
gptkbp:discoveredBy	gptkb:Stanley_Cohen
gptkbp:encodedBy	gptkb:EGFR_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000146648
gptkbp:expressedIn	gptkb:cancer gptkb:skin gptkb:kidney gptkb:placenta gptkb:prostate brain heart liver colon pancreas epithelial tissues
gptkbp:function	gptkb:receptor_tyrosine_kinase
gptkbp:gene	gptkb:EGFR
gptkbp:HGNC_ID	3236
https://www.w3.org/2000/01/rdf-schema#label	epidermal growth factor receptor (EGFR)
gptkbp:involvedIn	gptkb:cancer cell differentiation cell proliferation cell survival
gptkbp:length	1210 amino acids
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	gptkb:7p11.2
gptkbp:memberOf	ERBB family
gptkbp:molecularWeight	134 kDa
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:L858R gptkb:T790M gptkb:glioblastoma colorectal cancer exon 19 deletion
gptkbp:OMIM	131550
gptkbp:overexpressedIn	gptkb:non-small_cell_lung_cancer gptkb:glioblastoma colorectal cancer head and neck cancer
gptkbp:PDB	1M17
gptkbp:phosphorylates	itself (autophosphorylation)
gptkbp:RefSeq	NM_005228
gptkbp:target	gptkb:afatinib gptkb:cetuximab gptkb:erlotinib gptkb:gefitinib gptkb:osimertinib gptkb:panitumumab
gptkbp:UniProtID	gptkb:P00533
gptkbp:bfsParent	gptkb:EGFR_inhibitors_(in_colorectal_cancer) gptkb:epidermal_growth_factor_(EGF) gptkb:transforming_growth_factor_alpha_(TGF-α)
gptkbp:bfsLayer	7