cyclin-dependent kinase 4

URI: https://gptkb.org/entity/cyclin-dependent_kinase_4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:cell_division_protein_kinase_4 gptkb:CDK4
gptkbp:associatedWith	gptkb:cancer melanoma
gptkbp:discoveredBy	1992
gptkbp:domain	protein kinase domain
gptkbp:EC_number	2.7.11.22
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000135446 gptkb:CDK4
gptkbp:expressedIn	many tissues
gptkbp:formsComplexWith	D-type cyclins
gptkbp:function	serine/threonine kinase activity
gptkbp:gene	gptkb:CDK4
gptkbp:has_cofactor	Mg2+
gptkbp:hasIsoform	CDK4 isoform 1 CDK4 isoform 2
gptkbp:HGNC_ID	1773
https://www.w3.org/2000/01/rdf-schema#label	cyclin-dependent kinase 4
gptkbp:inhibitedBy	gptkb:p15INK4b gptkb:p16INK4a gptkb:p18INK4c gptkb:p19INK4d
gptkbp:involves	gptkb:PI3K-Akt_signaling_pathway cell cycle regulation p53 signaling pathway cell cycle pathway
gptkbp:locatedIn	gptkb:nucleus gptkb:cytoplasm
gptkbp:locatedOnChromosome	12q14
gptkbp:molecularWeight	34 kDa
gptkbp:OMIM	123829
gptkbp:orthologInMouse	gptkb:Cdk4
gptkbp:PDB	gptkb:2W96
gptkbp:phosphorylates	gptkb:retinoblastoma_protein_(pRb) threonine 172
gptkbp:product	gptkb:CDK4_gene
gptkbp:RefSeq	gptkb:NM_000075
gptkbp:regulates	gptkb:cyclin_D CDK inhibitors (e.g., p16INK4a)
gptkbp:requires	G1/S cell cycle transition
gptkbp:target	gptkb:palbociclib gptkb:ribociclib gptkb:abemaciclib
gptkbp:UniProtID	P11802
gptkbp:bfsParent	gptkb:lerociclib gptkb:v-cyclin
gptkbp:bfsLayer	8