Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:activatedBy |
inflammasome
|
| gptkbp:alternativeName |
gptkb:ICE
interleukin-1 beta converting enzyme |
| gptkbp:cleavage |
p10 subunit
p20 subunit |
| gptkbp:discoveredBy |
1992
|
| gptkbp:EC_number |
3.4.22.36
|
| gptkbp:encodedBy |
CASP1 gene
|
| gptkbp:function |
gptkb:cysteine_protease
involved in inflammation cleaves pro-IL-18 cleaves pro-IL-1β |
| gptkbp:gene |
CASP1
|
| https://www.w3.org/2000/01/rdf-schema#label |
caspase-1
|
| gptkbp:inhibitedBy |
caspase inhibitors
|
| gptkbp:involvedIn |
innate immune response
pyroptosis |
| gptkbp:locatedIn |
cytosol
|
| gptkbp:locatedOnChromosome |
human chromosome 11q22.2-q22.3
|
| gptkbp:molecularWeight |
45 kDa (precursor)
|
| gptkbp:OMIM |
147678
|
| gptkbp:relatedTo |
caspase-5
caspase-4 caspase-11 |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
homodimer
|
| gptkbp:UniProtID |
P29466
|
| gptkbp:bfsParent |
gptkb:NOD-like_receptors
gptkb:caspases |
| gptkbp:bfsLayer |
7
|