Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:activatedBy |
gptkb:caspase-1
|
| gptkbp:alternativeName |
catabolin
interleukin-1 beta leukocytic pyrogen |
| gptkbp:discoveredBy |
Jean-Michel Dayer
|
| gptkbp:discoveredIn |
1974
|
| gptkbp:encodedBy |
IL1B gene
|
| gptkbp:Entrez_Gene_ID |
3553
|
| gptkbp:function |
mediates inflammatory response
induces fever promotes leukocyte infiltration stimulates production of acute-phase proteins |
| gptkbp:halfLife |
~2 hours in plasma
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-1β
|
| gptkbp:inhibitedBy |
gptkb:canakinumab
gptkb:anakinra rilonacept |
| gptkbp:involvedIn |
sepsis
autoimmune diseases gout rheumatoid arthritis inflammatory bowel disease |
| gptkbp:locatedOnChromosome |
2q14
|
| gptkbp:memberOf |
interleukin-1 family
|
| gptkbp:molecularWeight |
17 kDa
|
| gptkbp:OMIM |
147720
|
| gptkbp:PDB |
2I1B
|
| gptkbp:postTranslationalModification |
proteolytic cleavage
|
| gptkbp:predecessor |
pro-IL-1β
|
| gptkbp:producedBy |
dendritic cells
monocytes activated macrophages |
| gptkbp:promotion |
production of IL-6
osteoclast differentiation expression of adhesion molecules matrix metalloproteinase production production of TNF-α production of prostaglandins |
| gptkbp:recipient |
IL-1 receptor type I
IL-1 receptor type II |
| gptkbp:role |
host defense
tissue destruction in chronic inflammation |
| gptkbp:secretes |
unconventional protein secretion pathway
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
single polypeptide chain
|
| gptkbp:UniProtID |
P01584
|
| gptkbp:bfsParent |
gptkb:IL-1
gptkb:canakinumab |
| gptkbp:bfsLayer |
7
|