Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:caspase-1
gptkb:NF-kB_pathway inflammatory signaling pathways |
| gptkbp:alsoKnownAs |
NLRs
|
| gptkbp:containDomain |
leucine-rich repeat domain
NACHT domain NOD domain |
| gptkbp:detect |
danger-associated molecular patterns
pathogen-associated molecular patterns |
| gptkbp:discoveredIn |
early 2000s
|
| gptkbp:domain |
C-terminal LRR
N-terminal effector domain central NACHT |
| gptkbp:encodedBy |
NLR genes
|
| gptkbp:example |
gptkb:NOD2
gptkb:NOD1 NLRC4 NLRP3 |
| gptkbp:form |
inflammasome
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
innate immune response
|
| https://www.w3.org/2000/01/rdf-schema#label |
NOD-like receptors
|
| gptkbp:involvedIn |
apoptosis
recognition of viral RNA pyroptosis recognition of bacterial peptidoglycan recognition of cellular stress |
| gptkbp:locale |
gptkb:cytoplasm
|
| gptkbp:N-terminal_domain |
gptkb:PYD
gptkb:BIR CARD acidic transactivation domain |
| gptkbp:regulates |
inflammation
cell death cytokine production |
| gptkbp:relatedTo |
gptkb:Toll-like_receptors
|
| gptkbp:role |
gptkb:Crohn's_disease
gout rheumatoid arthritis autoinflammatory diseases host defense |
| gptkbp:structure |
tripartite
|
| gptkbp:subfamily |
gptkb:NLRB
gptkb:NLRC NLRA NLRP |
| gptkbp:bfsParent |
gptkb:LRR
|
| gptkbp:bfsLayer |
6
|