cAMP-dependent protein kinase
GPTKB entity
Statements (99)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
PKA
|
| gptkbp:activatedBy |
cyclic AMP
|
| gptkbp:alsoKnownAs |
gptkb:protein_kinase_A
|
| gptkbp:composedOf |
catalytic subunits
regulatory subunits |
| gptkbp:discoveredBy |
gptkb:Earl_Sutherland
|
| gptkbp:EC_number |
2.7.11.11
|
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
phosphorylates serine/threonine residues
|
| gptkbp:gene |
gptkb:PRKACA
gptkb:PRKACB gptkb:PRKACG gptkb:PRKAR1B gptkb:PRKAR2A gptkb:PRKAR2B gptkb:PRKAR1A |
| https://www.w3.org/2000/01/rdf-schema#label |
cAMP-dependent protein kinase
|
| gptkbp:inhibitedBy |
protein kinase inhibitor peptide
|
| gptkbp:involvedIn |
signal transduction
regulation of metabolism |
| gptkbp:regulates |
gptkb:MAPK_pathway
gptkb:glycogen_synthase gptkb:Bcl-2_family_proteins gptkb:CREB gptkb:urea_cycle gptkb:myosin_light_chain_kinase gptkb:AMPA_receptors gptkb:BAD_protein gptkb:mTOR_pathway gptkb:synaptic_plasticity gptkb:GABA_receptors gptkb:L-type_calcium_channels gptkb:phospholamban gptkb:troponin_I gptkb:Na+/K+_ATPase apoptosis cell differentiation wound healing DNA repair gene expression lipid metabolism cellular senescence mitochondrial function angiogenesis cell growth cell migration protein synthesis transcription factors metastasis immune response muscle contraction oxidative phosphorylation cell cycle glycogen metabolism protein degradation glycolysis cellular metabolism autophagy amino acid metabolism antioxidant defense cell adhesion cytoskeletal dynamics fatty acid oxidation inflammatory response insulin secretion neuronal excitability tumorigenesis erythropoiesis glucagon secretion ion channel activity memory formation hematopoiesis renal function pain perception gluconeogenesis bile acid synthesis cardiac function cholesterol synthesis chondrogenesis platelet aggregation steroidogenesis voltage-gated potassium channels osteogenesis hormone secretion liver metabolism phosphorylase kinase oocyte maturation vascular tone reactive oxygen species production adipocyte lipolysis leukocyte activation melatonin synthesis sperm motility thyroid hormone production |
| gptkbp:structure |
tetramer
|
| gptkbp:bfsParent |
gptkb:protein_kinase_A
gptkb:hormone-sensitive_lipase |
| gptkbp:bfsLayer |
7
|