|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
PKR2B
PRKARII-beta
RII-beta
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Carney_complex
|
|
gptkbp:encodes
|
cAMP-dependent protein kinase type II-beta regulatory subunit
|
|
gptkbp:Entrez_Gene_ID
|
5577
ENSG00000108651
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
adipose tissue
|
|
gptkbp:function
|
regulatory subunit of cAMP-dependent protein kinase (PKA)
|
|
gptkbp:gene
|
gptkb:PRKAR2B
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0005634
GO:0005737
GO:0005524
GO:0004691
|
|
gptkbp:HGNC_ID
|
9380
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRKAR2B
|
|
gptkbp:interactsWith
|
gptkb:PRKACA
gptkb:PRKACB
AKAP9
AKAP1
|
|
gptkbp:involvedIn
|
gptkb:cAMP_signaling_pathway
|
|
gptkbp:length
|
416 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q22.3
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:mutationAssociatedWith
|
altered PKA signaling
|
|
gptkbp:OMIM
|
176911
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Prkar2b
|
|
gptkbp:phosphorylates
|
Serine 114
Serine 99
|
|
gptkbp:proteinFamily
|
protein kinase A regulatory subunits
|
|
gptkbp:referenceGenome
|
NM_002735
|
|
gptkbp:referenceSequenceProtein
|
NP_002726
|
|
gptkbp:regulates
|
activated by cAMP
PKA catalytic activity
|
|
gptkbp:significance
|
potential role in mood disorders
potential role in obesity
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:subunit
|
cAMP-dependent protein kinase type II
|
|
gptkbp:UniProtID
|
P31323
|
|
gptkbp:bfsParent
|
gptkb:protein_kinase_A
|
|
gptkbp:bfsLayer
|
7
|