|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:binds
|
gptkb:gamma-aminobutyric_acid
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
various genes
|
|
gptkbp:enemyOf
|
gptkb:bicuculline
gptkb:muscimol
gptkb:isoguvacine
gptkb:picrotoxin
baclofen (GABA_B)
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
retina
peripheral nervous system
|
|
gptkbp:foundIn
|
central nervous system
|
|
gptkbp:function
|
mediate inhibitory neurotransmission
|
|
gptkbp:GABA_A_receptor
|
gptkb:voltage-gated_potassium_channel
|
|
gptkbp:GABA_B_receptor
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:GABA_C_receptor
|
ionotropic receptor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GABA receptors
|
|
gptkbp:involvedIn
|
epilepsy
muscle relaxation
anxiety regulation
sleep regulation
|
|
gptkbp:location
|
postsynaptic membrane
presynaptic membrane (GABA_B)
|
|
gptkbp:modulatedBy
|
gptkb:beer
gptkb:benzodiazepines
barbiturates
general anesthetics
neurosteroids
|
|
gptkbp:mutationAssociatedWith
|
epilepsy
insomnia
anxiety disorders
|
|
gptkbp:permeableTo
|
chloride ions
potassium ions (GABA_B)
|
|
gptkbp:relatedTo
|
dopamine receptors
serotonin receptors
glutamate receptors
|
|
gptkbp:structure
|
heterodimeric (GABA_B)
pentameric (GABA_A)
|
|
gptkbp:subspecies
|
gptkb:GABA_A_receptor
gptkb:GABA_B_receptor
gptkb:GABA_C_receptor
|
|
gptkbp:target
|
anticonvulsant drugs
anxiolytic drugs
muscle relaxants
sedative drugs
hypnotic drugs
|
|
gptkbp:bfsParent
|
gptkb:GABAergic_system
gptkb:gamma-aminobutyric_acid_signaling_pathway
gptkb:cAMP-dependent_protein_kinase
|
|
gptkbp:bfsLayer
|
8
|