Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
voltage-gated calcium channel
|
| gptkbp:activatedBy |
membrane depolarization
|
| gptkbp:activationThreshold |
high voltage
|
| gptkbp:alternativeName |
CaV1 channels
long-lasting calcium channels |
| gptkbp:blockedIn |
benzothiazepines
dihydropyridines phenylalkylamines |
| gptkbp:conductance |
high
|
| gptkbp:discoveredBy |
gptkb:Albrecht_Fleckenstein
|
| gptkbp:discoveredIn |
1960s
|
| gptkbp:encodedBy |
CACNA1C
CACNA1S CACNA1F CACNA1D |
| gptkbp:foundIn |
gptkb:skeletal_muscle
cardiac muscle neurons smooth muscle |
| gptkbp:hasIsoform |
CaV1.1
CaV1.2 CaV1.3 CaV1.4 |
| https://www.w3.org/2000/01/rdf-schema#label |
L-type calcium channels
|
| gptkbp:inactivation |
slow
|
| gptkbp:mutationAssociatedWith |
gptkb:Brugada_syndrome
gptkb:arrhythmia congenital stationary night blindness Timothy syndrome |
| gptkbp:permeableTo |
calcium ions
|
| gptkbp:proteinFamily |
CACNA1
|
| gptkbp:role |
gptkb:synaptic_plasticity
neurotransmitter release gene expression regulation cardiac action potential insulin secretion excitation-contraction coupling hormone secretion auditory transduction pacemaker activity visual transduction |
| gptkbp:subunit |
beta subunit
gamma subunit alpha1 subunit alpha2delta subunit |
| gptkbp:targetOfDrug |
calcium channel blockers
antiarrhythmic drugs antihypertensive drugs |
| gptkbp:bfsParent |
gptkb:cAMP-dependent_protein_kinase
|
| gptkbp:bfsLayer |
8
|