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gptkbp:instanceOf
|
biological pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:ornithine_cycle
|
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gptkbp:compartmentalization
|
partly mitochondrial, partly cytosolic
|
|
gptkbp:energy_requirement
|
requires ATP
|
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gptkbp:enzyme
|
gptkb:arginase
gptkb:argininosuccinate_lyase
gptkb:argininosuccinate_synthetase
gptkb:carbamoyl_phosphate_synthetase_I
gptkb:ornithine_transcarbamylase
|
|
gptkbp:firstDescribed
|
gptkb:Hans_Krebs
1932
|
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gptkbp:function
|
converts ammonia to urea
|
|
gptkbp:gene
|
gptkb:ASL
gptkb:OTC
gptkb:ASS1
gptkb:CPS1
ARG1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
urea cycle
|
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gptkbp:importantFor
|
removes toxic ammonia from body
|
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gptkbp:location
|
liver
mitochondria
cytosol
|
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gptkbp:medium
|
arginine
argininosuccinate
citrulline
ornithine
|
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gptkbp:product
|
gptkb:urea
fumarate
|
|
gptkbp:regulates
|
N-acetylglutamate
|
|
gptkbp:relatedTo
|
amino acid catabolism
nitrogen metabolism
|
|
gptkbp:significance
|
hyperammonemia
|
|
gptkbp:species
|
amphibians
mammals
some fish
|
|
gptkbp:substrate
|
carbon dioxide
ammonia
|
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gptkbp:suffersFrom
|
argininemia
argininosuccinic aciduria
carbamoyl phosphate synthetase I deficiency
citrullinemia
ornithine transcarbamylase deficiency
|
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gptkbp:bfsParent
|
gptkb:Hans_Adolf_Krebs
|
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gptkbp:bfsLayer
|
4
|