|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alias
|
gptkb:ABL1
JTK7
p150
v-abl Abelson murine leukemia viral oncogene homolog 1
|
|
gptkbp:alternativeSplicing
|
ABL1a
ABL1b
|
|
gptkbp:associatedWith
|
leukemia
solid tumors
|
|
gptkbp:discoveredBy
|
H. Hanafusa
|
|
gptkbp:encodedBy
|
gptkb:ABL1_gene
|
|
gptkbp:Entrez_Gene_ID
|
25
|
|
gptkbp:enzymeCommissionNumber
|
2.7.10.2
|
|
gptkbp:function
|
cell differentiation
signal transduction
cell division
cell adhesion
stress response
|
|
gptkbp:HGNC_ID
|
76
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Abl
|
|
gptkbp:inhibitedBy
|
gptkb:dasatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:interactsWith
|
gptkb:GRB2
gptkb:BRCA1
gptkb:p53
gptkb:STAT5
FYN
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q34
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:OMIM
|
189980
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
Drosophila Abl
mouse Abl1
|
|
gptkbp:PDB
|
2FO0
1OPL
2G2F
|
|
gptkbp:phosphorylates
|
gptkb:p73
gptkb:RNA_polymerase_II
gptkb:CRK
gptkb:RAD51
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
myristoylation
|
|
gptkbp:relatedTo
|
gptkb:chronic_myeloid_leukemia
gptkb:BCR-ABL_fusion_protein
|
|
gptkbp:structure
|
SH2 domain
SH3 domain
tyrosine kinase domain
|
|
gptkbp:UniProtID
|
P00519
|
|
gptkbp:bfsParent
|
gptkb:PTPN12
|
|
gptkbp:bfsLayer
|
7
|