Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:accumulatesIn |
extracellular space
|
| gptkbp:aggregatesInto |
fibrils
oligomers |
| gptkbp:alsoKnownAs |
gptkb:Aβ
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:cleavage |
gptkb:amyloid_precursor_protein
|
| gptkbp:component |
senile plaques
|
| gptkbp:composedOf |
amino acids
|
| gptkbp:degradedBy |
gptkb:neprilysin
gptkb:insulin-degrading_enzyme |
| gptkbp:discoveredIn |
1984
|
| gptkbp:encodedBy |
gptkb:APP_gene
|
| gptkbp:firstDescribed |
gptkb:Caine_Wong
gptkb:George_Glenner |
| gptkbp:form |
amyloid plaques
|
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:hasIsoform |
gptkb:Aβ40
gptkb:Aβ42 |
| https://www.w3.org/2000/01/rdf-schema#label |
amyloid beta protein
|
| gptkbp:involves |
neurodegeneration
|
| gptkbp:length |
36-43 amino acids
|
| gptkbp:producedBy |
proteolytic cleavage
|
| gptkbp:structure |
beta sheet
|
| gptkbp:studiedIn |
neuroscience
|
| gptkbp:target |
Alzheimer's disease therapies
|
| gptkbp:toxicity |
neurons
|
| gptkbp:bfsParent |
gptkb:Aduhelm
gptkb:Donanemab |
| gptkbp:bfsLayer |
6
|