tropomyosin receptor kinase A

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:TrkA gptkb:neurotrophic_tyrosine_kinase_receptor_type_1
gptkbp:biologicalProcess	protein kinase activity transmembrane receptor activity
gptkbp:discoveredBy	gptkb:L._F._Reichardt
gptkbp:discoveredIn	1991
gptkbp:encodedBy	gptkb:NTRK1_gene
gptkbp:foundIn	humans mammals
gptkbp:function	binds nerve growth factor (NGF) mediates neuronal differentiation mediates neuronal survival
https://www.w3.org/2000/01/rdf-schema#label	tropomyosin receptor kinase A
gptkbp:involvedIn	gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway gptkb:neurotrophin_signaling_pathway
gptkbp:locatedOnChromosome	gptkb:chromosome_1q21-q22_(human)
gptkbp:location	gptkb:plasma_membrane
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:congenital_insensitivity_to_pain_with_anhidrosis
gptkbp:target	gptkb:entrectinib gptkb:larotrectinib
gptkbp:UniProtID	gptkb:P04629
gptkbp:bfsParent	gptkb:TrkA
gptkbp:bfsLayer	6