|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MAPK_pathway
gptkb:NF-κB_pathway
|
|
gptkbp:alternativeName
|
gptkb:CD284
|
|
gptkbp:associatedWith
|
asthma
atherosclerosis
sepsis
inflammatory diseases
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Beutler
|
|
gptkbp:domain
|
TIR domain
leucine-rich repeat (LRR)
|
|
gptkbp:encodedBy
|
gptkb:TLR4_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000136869
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
endothelial cells
monocytes
epithelial cells
|
|
gptkbp:formsComplexWith
|
gptkb:CD14
gptkb:MD-2
|
|
gptkbp:fullName
|
gptkb:Toll-like_receptor_4
|
|
gptkbp:function
|
innate immune response
pattern recognition receptor
|
|
gptkbp:gene
|
gptkb:TLR4
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11850
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TLR4
|
|
gptkbp:interactsWith
|
gptkb:TRAM
MyD88
TRIF
TIRAP
|
|
gptkbp:length
|
839
|
|
gptkbp:locatedOnChromosome
|
9q33.1
|
|
gptkbp:location
|
gptkb:endosome
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
96 kDa
|
|
gptkbp:mutationAssociatedWith
|
Gram-negative bacterial infections
endotoxin hyporesponsiveness
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
|
|
gptkbp:pathway
|
gptkb:Toll-like_receptor_signaling_pathway
MyD88-dependent pathway
TRIF-dependent pathway
|
|
gptkbp:PDB
|
3FXI
|
|
gptkbp:recognizedBy
|
lipopolysaccharide
bacterial lipopolysaccharide (LPS)
|
|
gptkbp:RefSeq
|
NM_138554
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:UniProtID
|
O00206
|
|
gptkbp:bfsParent
|
gptkb:CD14
gptkb:Toll-like_receptor_4_(TLR4)
|
|
gptkbp:bfsLayer
|
6
|