|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD284
Toll/interleukin-1 receptor-like protein 4
hToll
|
|
gptkbp:associatedWith
|
asthma
sepsis
inflammatory diseases
innate immune response
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
gptkb:Toll-like_receptor_4
|
|
gptkbp:Entrez_Gene_ID
|
7099
ENSG00000136869
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:function
|
activation of NF-kappaB pathway
recognition of lipopolysaccharide (LPS)
|
|
gptkbp:HGNC_ID
|
11850
|
|
gptkbp:interactsWith
|
gptkb:LPS
gptkb:CD14
MD-2 protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
9q33.1
|
|
gptkbp:mutationAssociatedWith
|
endotoxin hyporesponsiveness
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Tlr4
|
|
gptkbp:pathway
|
gptkb:Toll-like_receptor_signaling_pathway
MyD88-dependent pathway
TRIF-dependent pathway
|
|
gptkbp:product
|
TLR4 protein
|
|
gptkbp:significance
|
biomarker for inflammatory diseases
target for immunotherapy
|
|
gptkbp:UniProtID
|
O00206
|
|
gptkbp:bfsParent
|
gptkb:CD284
gptkb:CD286
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TLR4 gene
|