|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatesPathway
|
gptkb:MAPK_signaling_pathway
gptkb:NF-kappaB_signaling_pathway
|
|
gptkbp:alternativeName
|
gptkb:CD284
Toll/interleukin-1 receptor-like protein 4
|
|
gptkbp:associatedWith
|
asthma
atherosclerosis
sepsis
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
immune response
inflammatory response
transmembrane signaling receptor activity
|
|
gptkbp:cellularComponent
|
gptkb:endosome
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Bruce_Beutler
|
|
gptkbp:domain
|
leucine-rich repeat
TIR domain
|
|
gptkbp:encodedBy
|
gptkb:TLR4_gene
|
|
gptkbp:Entrez_Gene_ID
|
7099
ENSG00000136869
|
|
gptkbp:expressedIn
|
dendritic cells
macrophages
endothelial cells
monocytes
epithelial cells
|
|
gptkbp:formsComplexWith
|
gptkb:CD14
gptkb:MD-2
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
innate immune response
pattern recognition receptor
|
|
gptkbp:HGNC_ID
|
11850
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Toll-like receptor 4
|
|
gptkbp:ligand
|
gptkb:lipid_A
gptkb:monophosphoryl_lipid_A
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4_(mouse)
gptkb:chromosome_9_(human)
|
|
gptkbp:OMIM
|
603030
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
3FXI
4G8A
|
|
gptkbp:recognizedBy
|
lipopolysaccharide
bacterial endotoxin
|
|
gptkbp:regulates
|
cytokine production
inflammatory signaling
|
|
gptkbp:symbol
|
gptkb:TLR4
|
|
gptkbp:UniProtID
|
O00206
|
|
gptkbp:bfsParent
|
gptkb:TLR4
gptkb:monophosphoryl_lipid_A
gptkb:CD284
gptkb:Lipopolysaccharide
gptkb:TLR4_gene
|
|
gptkbp:bfsLayer
|
7
|