|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:EPA
TIMP-1
CLGI
TIMP
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
inflammatory diseases
fibrosis
|
|
gptkbp:biologicalProcess
|
extracellular matrix organization
cellular response to cytokine stimulus
metalloendopeptidase inhibitor activity
negative regulation of endopeptidase activity
|
|
gptkbp:cellularComponent
|
extracellular region
extracellular space
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:encodes
|
TIMP1 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000102265
7076
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
Tissue Inhibitor of Metalloproteinases 1
|
|
gptkbp:function
|
involved in apoptosis
involved in cell proliferation
inhibits matrix metalloproteinases
involved in tissue remodeling
regulates extracellular matrix
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasParalog
|
gptkb:TIMP2_gene
gptkb:TIMP3_gene
gptkb:TIMP4_gene
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11820
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TIMP1 gene
|
|
gptkbp:length
|
5 exons
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:location
|
Xp11.3-p11.23
|
|
gptkbp:mutationAssociatedWith
|
can cause X-linked disorders
|
|
gptkbp:OMIM
|
305370
|
|
gptkbp:orthologIn
|
Timp1 (mouse)
|
|
gptkbp:pathway
|
gptkb:ECM-receptor_interaction
gptkb:Focal_adhesion
gptkb:Proteoglycans_in_cancer
|
|
gptkbp:product
|
gptkb:TIMP1
|
|
gptkbp:regulates
|
upregulated by cytokines
regulated by growth factors
|
|
gptkbp:significance
|
biomarker for cancer prognosis
potential therapeutic target
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:P01033
|
|
gptkbp:bfsParent
|
gptkb:TIMP1
|
|
gptkbp:bfsLayer
|
7
|