|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Metalloproteinase_inhibitor_1
TIMP-1
|
|
gptkbp:biologicalProcess
|
cell proliferation
apoptotic process
extracellular matrix organization
response to cytokine
negative regulation of endopeptidase activity
|
|
gptkbp:disulfideBond
|
present
|
|
gptkbp:encodedBy
|
Timp1 gene
|
|
gptkbp:Entrez_Gene_ID
|
21857
|
|
gptkbp:fullName
|
gptkb:Tissue_inhibitor_of_metalloproteinases_1
|
|
gptkbp:function
|
inhibits matrix metalloproteinases
regulates extracellular matrix
|
|
gptkbp:gene
|
Timp1
|
|
gptkbp:inhibitedBy
|
gptkb:MMP1
gptkb:MMP13
gptkb:MMP2
gptkb:MMP3
gptkb:MMP9
|
|
gptkbp:length
|
205 amino acids
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:location
|
secreted
|
|
gptkbp:modulatedBy
|
apoptosis
angiogenesis
cell growth
|
|
gptkbp:molecularWeight
|
23 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
human TIMP1
rat TIMP1
zebrafish timp1
|
|
gptkbp:pathway
|
gptkb:ECM-receptor_interaction
gptkb:Focal_adhesion
gptkb:Proteoglycans_in_cancer
|
|
gptkbp:PDB
|
gptkb:1UEA
|
|
gptkbp:postTranslationalModification
|
glycosylated
|
|
gptkbp:proteinFamily
|
gptkb:TIMP_family
|
|
gptkbp:RefSeq
|
NP_035728.1
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structure
|
contains NTR domain
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:kidney
brain
liver
spleen
|
|
gptkbp:UniProtID
|
ENSMUSP00000029059
P12031
|
|
gptkbp:bfsParent
|
gptkb:TIMP1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse TIMP1
|