Tissue inhibitor of metalloproteinases 1

URI: https://gptkb.org/entity/Tissue_inhibitor_of_metalloproteinases_1
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:TIMP1
gptkbp:alternativeName gptkb:EPA
Erythroid potentiating activity
gptkbp:discoveredBy 1985
gptkbp:domain C-terminal domain
N-terminal domain
gptkbp:encodedBy gptkb:TIMP1_gene
gptkbp:expressedIn gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:small_intestine
gptkb:testis
gptkb:thymus
brain
heart
liver
spleen
colon
pancreas
uterus
peripheral blood leukocytes
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function inhibits matrix metalloproteinases
regulates extracellular matrix
https://www.w3.org/2000/01/rdf-schema#label Tissue inhibitor of metalloproteinases 1
gptkbp:inhibitedBy gptkb:MMP1
gptkb:MMP13
gptkb:MMP3
gptkb:MMP9
gptkbp:locatedOnChromosome gptkb:Xp11.3–p11.23
gptkbp:molecularWeight 28 kDa
gptkbp:OMIM 305370
gptkbp:postTranslationalModification disulfide bonds
glycosylation
gptkbp:relatedTo cancer progression
tissue homeostasis
fibrosis
extracellular matrix remodeling
gptkbp:significance biomarker for cancer
biomarker for cardiovascular disease
biomarker for fibrosis
gptkbp:structure gptkb:protein
gptkbp:UniProtID gptkb:P01033
gptkbp:bfsParent gptkb:TIMP1
gptkbp:bfsLayer 7