Statements (41)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:virus
stress cytokines free radicals bacterial products |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases chronic inflammation |
| gptkbp:cause |
transcription of target genes
|
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:firstDescribed |
1986
|
| gptkbp:hasCanonicalPathway |
IKK-dependent pathway
|
| gptkbp:hasNonCanonicalPathway |
NIK-dependent pathway
|
| https://www.w3.org/2000/01/rdf-schema#label |
NF-κB signaling pathway
|
| gptkbp:inhibitedBy |
IκB proteins
|
| gptkbp:involves |
p50
p52 IκB kinase (IKK) complex RelA (p65) RelB c-Rel NF-κB protein complex phosphorylation of IκB |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:regulates |
apoptosis
cell proliferation inflammation immune response expression of adhesion molecules expression of anti-apoptotic proteins expression of chemokines expression of cytokines |
| gptkbp:result |
nuclear translocation of NF-κB
|
| gptkbp:target |
therapeutic drugs
anti-inflammatory agents |
| gptkbp:bfsParent |
gptkb:TAK1
gptkb:IKK |
| gptkbp:bfsLayer |
7
|