superoxide dismutase 2, mitochondrial

URI: https://gptkb.org/entity/superoxide_dismutase_2,_mitochondrial
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:MnSOD
gptkbp:associated_with_aging yes
gptkbp:associated_with_apoptosis yes
gptkbp:associated_with_inflammation yes
gptkbp:associatedWith gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
gptkbp:biologicalProcess antioxidant activity
response to oxidative stress
gptkbp:cofactor manganese
gptkbp:discoveredBy 1973
gptkbp:EC_number 1.15.1.1
gptkbp:Entrez_Gene_ID 6648
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
gptkbp:function catalyzes dismutation of superoxide radicals
gptkbp:gene gptkb:SOD2
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 11179
https://www.w3.org/2000/01/rdf-schema#label superoxide dismutase 2, mitochondrial
gptkbp:length 222
gptkbp:locatedIn mitochondrion
gptkbp:locatedOnChromosome 6q25.3
gptkbp:molecularWeight 24 kDa
gptkbp:mutationAssociatedWith mitochondrial dysfunction
increased oxidative stress
gptkbp:OMIM 147460
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Sod2
gptkbp:orthologInYeast gptkb:SOD2
gptkbp:pathway oxidative phosphorylation
cellular response to stress
reactive oxygen species detoxification
gptkbp:PDB gptkb:1LUV
gptkbp:postTranslationalModification phosphorylation
methylation
acetylation
gptkbp:proteinFamily gptkb:iron/manganese_superoxide_dismutase_family
gptkbp:RefSeq NP_000627.2
gptkbp:subunit homotetramer
gptkbp:UniProtID P04179
gptkbp:bfsParent gptkb:SOD2
gptkb:Sod2
gptkbp:bfsLayer 7