|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Cu,Zn-SOD
gptkb:Fe-SOD
gptkb:Mn-SOD
gptkb:extracellular_SOD
|
|
gptkbp:associatedWith
|
gptkb:familial_ALS
amyotrophic lateral sclerosis
oxidative stress
|
|
gptkbp:cofactor
|
copper
iron
zinc
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Joe_McCord
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:foundIn
|
aerobic organisms
|
|
gptkbp:fullName
|
gptkb:superoxide_dismutase
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD2
gptkb:SOD3
gptkb:SOD1
|
|
gptkbp:hasIsoform
|
gptkb:SOD2
gptkb:SOD3
gptkb:SOD1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SOD
|
|
gptkbp:locatedOnChromosome
|
21q22.11 (SOD1)
4p15.3-p15.1 (SOD3)
6q25.3 (SOD2)
|
|
gptkbp:medicalUse
|
potential therapeutic agent for oxidative stress
|
|
gptkbp:organism
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Bacteria
|
|
gptkbp:PDB
|
gptkb:1CB4
1AP5
|
|
gptkbp:role
|
protects cells from superoxide toxicity
|
|
gptkbp:SOD1Location
|
gptkb:cytoplasm
|
|
gptkbp:SOD2Location
|
mitochondria
|
|
gptkbp:SOD3Location
|
extracellular
|
|
gptkbp:structure
|
glycosylated (SOD3)
homodimer (SOD1)
homotetramer (SOD2)
|
|
gptkbp:type
|
2 O2- + 2 H+ → O2 + H2O2
antioxidant enzyme
|
|
gptkbp:UniProtID
|
gptkb:P00441
P04179
P08294
|
|
gptkbp:bfsParent
|
gptkb:DEA_Special_Operations_Division
|
|
gptkbp:bfsLayer
|
5
|