|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Mn-SOD
gptkb:IPO-B
gptkb:MNSOD
gptkb:SODM
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
|
|
gptkbp:clinicalTrialPhase
|
SOD2 polymorphism and disease risk
|
|
gptkbp:cofactor
|
manganese
|
|
gptkbp:component
|
mitochondrion
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112096
gptkb:rs4880
6647
|
|
gptkbp:enzymeCommissionNumber
|
1.15.1.1
|
|
gptkbp:fullName
|
gptkb:superoxide_dismutase_2
|
|
gptkbp:function
|
catalyzes dismutation of superoxide radicals
|
|
gptkbp:gene
|
gptkb:SOD2
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOMolecularFunction
|
superoxide dismutase activity
|
|
gptkbp:GOProcess
|
cellular response to reactive oxygen species
response to oxidative stress
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11179
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hsa:6647
|
|
gptkbp:length
|
222 amino acids
|
|
gptkbp:locatedOnChromosome
|
6
6q25.3
|
|
gptkbp:molecularWeight
|
24.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
mutations can cause mitochondrial dysfunction
|
|
gptkbp:OMIM
|
147460
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Sod2
|
|
gptkbp:pathway
|
oxidative phosphorylation
reactive oxygen species degradation
|
|
gptkbp:PDB
|
gptkb:1LUV
gptkb:1N0J
1AP5
|
|
gptkbp:product
|
gptkb:mitochondrial_superoxide_dismutase
|
|
gptkbp:promotion
|
TATA-less
|
|
gptkbp:proteinFamily
|
gptkb:superoxide_dismutase_family
|
|
gptkbp:regulates
|
induced by oxidative stress
regulated by NF-kB
|
|
gptkbp:subcellularLocation
|
mitochondrial matrix
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P04179
|
|
gptkbp:bfsParent
|
gptkb:SOD1
|
|
gptkbp:bfsLayer
|
5
|