superoxide dismutase [Mn], mitochondrial

URI: https://gptkb.org/entity/superoxide_dismutase_[Mn],_mitochondrial
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:MnSOD
SOD2 protein
gptkbp:associatedWith gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
gptkbp:biologicalProcess antioxidant activity
cellular response to oxidative stress
response to oxidative stress
superoxide dismutase activity
gptkbp:cellularComponent mitochondrion
gptkbp:cofactor manganese
gptkbp:Entrez_Gene_ID GC06P160
gptkbp:enzymeCommissionNumber 1.15.1.1
gptkbp:function catalyzes dismutation of superoxide radicals
gptkbp:gene gptkb:SOD2
gptkbp:geneType protein-coding
gptkbp:hasIsoform mitochondrial
gptkbp:HGNC_ID 11179
https://www.w3.org/2000/01/rdf-schema#label superoxide dismutase [Mn], mitochondrial
gptkbp:length 222
gptkbp:locatedOnChromosome 6q25.3
gptkbp:location mitochondrion
gptkbp:molecularWeight 24 kDa
gptkbp:mutationAssociatedWith neurodegeneration
mitochondrial dysfunction
increased oxidative stress
gptkbp:OMIM 147460
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Sod2
gptkbp:pathway Detoxification of Reactive Oxygen Species
Reactive Oxygen Species Degradation
gptkbp:PDB gptkb:1LUV
gptkb:1N0J
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:protein_existence evidence at protein level
gptkbp:proteinFamily gptkb:superoxide_dismutase_family
Sod_Fe_C
Sod_Fe_N
gptkbp:RefSeq NP_000627.2
gptkbp:reviewedBy gptkb:UniProtKB/Swiss-Prot
gptkbp:subcellularLocation mitochondrial matrix
gptkbp:subunit homotetramer
gptkbp:tissue_specificity ubiquitous
gptkbp:UniProtID P04179
gptkbp:bfsParent gptkb:SOD2
gptkbp:bfsLayer 7