Manganese superoxide dismutase

URI: https://gptkb.org/entity/Manganese_superoxide_dismutase
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:MnSOD
gptkbp:associatedWith mitochondrial matrix
gptkbp:catalyzes dismutation of superoxide into oxygen and hydrogen peroxide
gptkbp:cofactor manganese
gptkbp:deficiencyCauses neurodegeneration
cardiomyopathy
premature aging in model organisms
gptkbp:discoveredBy 1973
gptkbp:EC_number 1.15.1.1
gptkbp:encodedBy SOD2 gene in humans
gptkbp:expressedIn all aerobic tissues
gptkbp:foundIn mitochondria
gptkbp:gene gptkb:SOD2
https://www.w3.org/2000/01/rdf-schema#label Manganese superoxide dismutase
gptkbp:inhibitedBy gptkb:diethyldithiocarbamate
hydroxylamine
gptkbp:involves cellular defense against reactive oxygen species
gptkbp:locatedOnChromosome chromosome 6q25.3 in humans
gptkbp:molecularWeight ~24 kDa per subunit
gptkbp:PDB gptkb:1LUV
gptkbp:presentIn eukaryotes
gptkbp:protectedBy oxidative stress
gptkbp:relatedTo gptkb:Cu/Zn_superoxide_dismutase
Fe superoxide dismutase
gptkbp:structure homotetramer in humans
gptkbp:UniProtID P04179
gptkbp:bfsParent gptkb:Mn-SOD
gptkb:SOD2
gptkb:MNSOD
gptkbp:bfsLayer 7